About this episode
Glucose Goddess Jessie Inchauspé exposes the pregnancy diet rewriting your baby’s DNA, how sugar in pregnancy spikes insulin, and the simple protein and supplement fixes most mothers miss! Jessie Inchauspé is a world-renowned biochemist and founder of the Glucose Goddess movement. She is the international bestselling author of books such as ‘The Glucose Goddess Method, and her latest book is ‘9 Months That Count Forever’. She explains: ◼️How glucose spikes in the womb program a baby’s future diabetes risk ◼️The 4 specific hacks to reduce blood sugar spikes by up to 75% ◼️Why eating 28 eggs a week is essential for infant brain development ◼️The link between glucose levels and ADHD ◼️How to stop sugar cravings in just 4 weeks Enjoyed the episode? Share this link and earn points for every referral - redeem them for exclusive prizes: https://doac-perks.com Follow Jessie: Instagram - https://link.thediaryofaceo.com/4qaUx1w YouTube - https://link.thediaryofaceo.com/DGazyDp TikTok - https://link.thediaryofaceo.com/6wk21Fo X - https://link.thediaryofaceo.com/EZGPu7m You can pre-order Jessie’s book ‘9 Months That Count Forever’, here: https://link.thediaryofaceo.com/6nFPyYW The Diary Of A CEO: ◼️Join DOAC circle here - https://doaccircle.com/ ◼️Buy The Diary Of A CEO book here - https://smarturl.it/DOACbook ◼️The 1% Diary is back - limited time only: https://bit.ly/3YFbJbt ◼️The Diary Of A CEO Conversation Cards (Second Edition): https://g2ul0.app.link/f31dsUttKKb ◼️Get email updates - https://bit.ly/diary-of-a-ceo-yt ◼️Follow Steven - https://g2ul0.app.link/gnGqL4IsKKb Sponsors: Cometeer: https://cometeer.com/steven for $30 off your first order Ketone - https://ketone.com/STEVEN for 30% off your subscription order WHOOP: https://JOIN.WHOOP.COM/CEO for one month free
Episode summary
What you eat in pregnancy helps set the dimmer switches on your baby’s genes, so I built a simple guide after diving into the science as a biochemist and new mom. Most women aren’t told they’re low on key nutrients like choline or that high sugar can program higher risks later, while steady protein supports growth.
Quick thank you for being here with us, and if you love these conversations, hit follow; it means the world. For those new to you, what have you spent the last decade focused on and why?
I’ve shown how daily blood sugar swings drive inflammation, faster aging, cravings, and fatigue. Glucose touches every system, so stabilizing it has been my foundation.
What’s new since we last spoke about sugar and spikes?
I’ve leaned into the mood and relationship effects; one study linked more glucose lows with more irritation toward partners. Mechanistically, unstable sugar can throw off neurotransmitters, which tracks with why crashes make us tense and reactive.
A crash tells your brain you’re out of fuel, so it flips into alert mode and cranks up cravings now, not later. Our modern ultra-sweet foods make spikes and drops fast and intense compared to the slower, steadier swings of our ancestors.
Even fruit’s been bred sweeter over time, right?
Yes—modern fruit is human-designed for sugar, but whole fruit’s fiber and water slow absorption; juice removes that brake. A glass of orange juice delivers roughly the same sugar load as soda, and one glass can hit the World Health Organization’s daily sugar limit.
Could sugar highs and lows feed behaviors like doomscrolling?
Sugar and scrolling both spike dopamine, so the brain’s reward pathways overlap; biology makes the pairing sticky. I haven’t seen definitive trials on doomscrolling, but the circuitry lines up.
I’m seeing research that a glucose crash creates an energy shortfall in the prefrontal cortex, which weakens self-control and nudges us toward quick dopamine hits; that resonates with my own experience.
When you’re on a sugar roller coaster, it stops feeling like a choice; the fix isn’t willpower, it’s preventing the crash. Protein helps most—your body will keep you hunting for food until it gets enough.
What do people message you about most?
They ask about specific foods and how to see through labels. “No added sugar” on juice is a classic trick, and badges like vegan or gluten-free don’t mean healthy.
We’re thinking about fertility; do both partners need to prepare?
Yes—sperm quality responds to a few months of better food, less alcohol, and exercise, and women’s nutrient reserves shape those early weeks. Both sides matter before conception.
Why write a pregnancy book now?
There’s a gulf between science and what parents hear; you’re not just an oven, you’re co-creating your baby’s biology. Diet nudges gene expression during this window, so you have agency.
Where are women most let down?
Our food environment and marketing steer moms toward ultra-processed choices, while guidance undersells epigenetics. High maternal glucose, for instance, can program higher diabetes vulnerability in the child.
Can you lay out the basics of what’s happening in pregnancy?
Early on the uterus feeds the embryo, then the placenta links your blood to the baby’s and nutrients flow with it. The myth that “the baby will take what it needs” isn’t true; the baby gets what you provide, which is why choline is huge for building memory and attention circuits.
How do you get enough choline, and what about liver?
Four eggs a day covers it cheaply; liver is rich but vitamin A guidelines vary, so check with your doctor if you eat it. A Cornell study showed babies of moms with higher choline reacted faster to visual tests, a marker tied to later cognitive performance.
What does the research say about breastfeeding?
Breast milk is bioactive and continues gene-level programming; formula is nutritionally complete but inert, so check it includes choline and DHA. Both can work, but composition matters.
I saw a study linking shorter breastfeeding to silencing of the leptin gene, which affects fullness.
That’s a clean epigenetic example, and it points to better satiety signaling with more breastfeeding. Sugar also crosses the placenta; a U.K. rationing natural experiment linked lower maternal sugar with less type 2 diabetes in offspring decades later.
Gestational diabetes also correlates with higher psychiatric risks in children.
A leading idea is that maternal inflammation over-activates microglia, the brain’s pruning cells, during neural wiring. Keeping spikes smaller can help keep inflammation down.
Are continuous glucose monitors useful in pregnancy?
Even a two-week window early on can teach you a lot, and first-trimester patterns predict who’s likely to develop gestational diabetes. Testing sooner would help many women adjust before problems escalate.
One study found first-trimester CGM data accurately forecasted who developed gestational diabetes later.
That challenges the idea it’s random; it often reflects pre-pregnancy glycemia. Fasting thresholds are well defined, post-meal spikes vary person to person, and the same simple hacks shrink spikes for everyone.
So muscle and movement help right after eating?
Yes—use the ninety-minute window after a meal; walking, squats, or even quiet calf raises pull glucose into working muscle. Start meals with vegetables to slow absorption, and you’ll see gentler curves.
We’ll test standing versus sitting after a muffin and show the results.
If standing uses more muscle, the spike should be smaller; if not, it’ll match sitting.
Should pregnant women exercise?
Yes—an animal study with tiny daily treadmill walks led to pups that solved mazes faster and showed less anxiety, likely via higher BDNF in mom and baby. Movement builds a better brain scaffold.
What’s your two-plant metaphor?
Same seed, different soil—one thrives in rich earth, one adapts in gravel; moms are the soil. Humans are resilient, but most women are low on choline, omega-3s, and protein while overdoing sugar, so better inputs still matter.
How should partners help, and what about alcohol?
Skip alcohol in pregnancy since your blood and the baby’s are connected; when breastfeeding you can time a drink so levels drop before the next feed. Keep caffeine modest—one to two cups looks fine—since high doses show issues in animals.
Fermented foods and bread?
Early signs suggest fermented foods may help seed the baby’s microbiome; in late pregnancy, the baby needs more glucose, so get it from starches like bread or rice, not candy. Whole fruit is fine, but skip fructose-heavy sweets; keto is risky, while low-glycemic is wiser.
Supplements—what did you take?
I ate fatty fish three times weekly and added DHA, took iron when low, and used a prenatal with choline and methylfolate; tinned sardines plus eggs cover a lot for little money.
You mentioned your first pregnancy—what happened?
I had a silent miscarriage discovered at the three-month scan, and the shock and grief were overwhelming. It’s common—about one in five—yet still taboo, so I felt alone even as many friends later shared they’d been through it.
What do you wish you’d known earlier?
I wish my family had spoken openly so I’d have been prepared; it often isn’t anything you did, and getting pregnant is harder than the warning messages of our youth suggest.
How has motherhood changed you?
My baseline happiness rose, and I became ruthlessly efficient with time because the baby comes first. I thought I was busy before; now I really am.
If prenatal inputs weren’t ideal, can adults still change course?
Yes—vulnerability isn’t destiny; stabilizing glucose and eating well can redirect your path. Culture shapes our habits, but we always have levers.
How do you think about cravings and that inner voice?
There’s the joyful “that looks tasty” voice and the urgent “I need sugar now” voice; tame the second by leveling glucose with a savory breakfast, veggie starters, and avoiding sugar on an empty stomach. And sometimes, if you’re wiped, have the cookie and move a little after—guilt doesn’t help, sleep and hormones drive cravings too.
Sleep loss raises ghrelin and lowers leptin, which explains those 4 a.m. hunger pangs.
Leptin links back to early-life programming, which is another reason this window matters.
What did we miss that’s crucial?
Protein—your baby is built from it, and low intake can program smaller muscle for life; aim high in the third trimester and protect your own lean mass. I used eggs plus three solid protein servings and a high-protein snack to get there.
Thoughts on GLP-1 drugs during pregnancy?
They blunt appetite when you need to eat well; I wouldn’t use them in pregnancy.
Is the vinegar trick safe for moms-to-be?
If you use pasteurized vinegar it’s fine, but the real win in pregnancy is cutting sugar rather than leaning on hacks.
Is obesity “genetic,” or is something else going on?
High sugar in the womb nudges genes toward fat storage; babies of high-glucose pregnancies are born with more fat and carry higher obesity risk later. That’s programming, not fate.
Did you think about evolution while writing?
We used to eat nutrient-dense organ meats and few processed foods; today’s ultra-processed landscape leaves moms depleted. I wrote this to cut through noise with clear, science-led steps so more babies start strong.
We haven’t touched stress yet, but it clearly belongs in this story too.
After a miscarriage, I spent my next pregnancy on edge despite all the yoga, breath work, workouts, and therapy; I skipped medication but could not switch off the fear, and thankfully my baby arrived healthy.
You made it through and now have a happy little one; would you want more children?
I’d love to, but it’s now a scheduling puzzle because I pack my calendar with work I love.
When you shop, what do you check on labels? I usually glance at carbs and sugar, probably from my keto days.
I go straight to the ingredients because they’re listed by weight; if sugar or sweeteners show up early, I file it under dessert and I avoid vague add-ons like natural flavors—sardines should just be fish, oil, and salt.
Macros tell you more than calories; the same calories from an avocado versus a donut lead to a steady day or a spike and crash.
Do you fast or follow a set eating rhythm?
No fasting; breakfast is eggs with coffee and whole milk, lunch starts with vegetables or a simple wrap, I enjoy a small sweet and a short walk after, and I keep most of my carbs for an early dinner like rice or pasta, often with vinegar on a veggie starter.
What’s next for you?
I’m diving deeper into mental health, which is why I began studying glucose in the first place, and I’m building new content projects I’m excited to share.
Our closing tradition: if you could change one thing to make the world better, what would you do?
I’d rein in food marketing, especially health halos on ultra-processed and sugary breakfast products, and I’d pull fruit juice from schools.
In your new book about how pregnancy diet shapes a child’s future, what’s the core message for expectant couples and, really, for all of us?
Pregnancy and our food environment are complicated, so I built a simple trimester plan that’s affordable and helps lay a strong foundation for your baby.
Could policy help here?
We need systems that make eggs, sardines, vegetables, and healthy fats easy for moms, plus better education—ninety percent of moms fall short on choline while only six percent of doctors bring it up, and I hope this book closes that gap, ideally handed to every new parent.
Friends who are pregnant tell me the advice feels like guesswork, so your science-grounded, stage-by-stage guide is a relief; it’s clear, concise, and a great gift we’ll revisit when it’s our turn.
It’s also perfect for grandparents to gift their kids; thanks for having me back, Stephen—it’s always a pleasure.