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The Diary Of A CEO with Steven Bartlett

Leaky Gut Expert: This Gut Mistake Leads To Cancer. The Cheap Spice That Helps Repair A Damaged Gut!

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PodcastThe Diary Of A CEO with Steven Bartlett
Publisher/creatorDOAC
Shortcast updated

About this episode

Tired of your health issues? Top gastroenterologist DR WILL BULSIEWICZ reveals NEW information about how leaky gut drives inflammation, cancer risk, bloating and brain fog, and the daily habits to heal FAST. Dr Will Bulsiewicz is one of the world’s leading experts on the gut microbiome. He is the US Medical Director at ZOE, a clinician at Lowcountry Gastroenterology Associates, and bestselling author of “Fibre Fueled” and the upcoming book, “Plant Powered Plus”. He explains: ◼️Why inflammation is driven by the gut, not just genetics ◼️How leaky gut triggers bloating and immune dysfunction ◼️The gut-immune link behind cancer and chronic disease ◼️Why fermented foods and fibre rebuild the microbiome ◼️How the gut-brain connection shapes mood, focus, and longevity (00:00) Intro (03:28) What Is Inflammation? (05:36) Can You Be Thin and Still Have Inflammation? (06:11) Why Does Chronic Inflammation Happen? (07:11) The Shocking Link Between Inflammation and Gut Health (10:47) Chronic Inflammation Causes These Diseases (12:17) The Importance of a Healthy Gut (12:52) Faecal Transplants to Heal the Gut (15:26) Link Between Gut Microbiome and Cancer (18:19) Parkinson's Could Start in the Gut (20:40) Can Anyone Get a Faecal Transplant? (21:22) A Lot of Us Have Gut Issues (23:37) Does Gas and Bloating Indicate a Health Issue? (31:34) Everyone Thinks They're Gluten Intolerant (32:36) Processing Issues With Gluten (35:04) Is Sourdough the Best Bread? (36:13) Your Gluten Intolerance Might Be This Instead (38:18) How Long Does It Take to Repair the Gut? (41:17) What Causes Bowel Diseases? (42:42) Antibiotics Double Your Risk of Bowel Disease (43:16) Fixing a Chronic Gut Issue With a Fecal Transplant (47:46) What Diet Trends Spread Misinformation? (51:54) Fibremaxxing and the Importance of Fibre (54:48) Best Foods to Eat for Fibre (59:11) How Fibre Affects Immunity and Ageing (1:00:00) This Is What Alcohol Does to the Gut (1:05:34) Ads (1:07:24) Benefits of Turmeric (1:09:22) Dr Will's Perfect Gut Day (1:19:40) Good Breakfast for Children (1:20:44) What Would Impact Your Child's Gut Health? (1:25:22) Dr Will's Perfect Gut Day (1:33:19) Optimal Time to Workout (1:34:56) Perfect Time Between Meals (1:35:54) Perfect Evening Routine (1:39:23) Would You Recommend Fasting? (1:42:21) Ads (1:44:18) Trauma Impacts Gut Function (1:49:35) How Would I Heal My Trauma-Related Gut Issues? (1:50:42) Stool Test – Is Your Gut Healthy? (1:53:33) Magnesium for Constipation and Sleep (1:55:03) This Is Easier Than You Think – 4 Things You Need (1:58:58) Dr Will's Transformation (2:05:02) Message to My Dad (2:09:34) Your Biggest Regret Follow Dr Will: Instagram - https://bit.ly/457iRAx The Gut Health MD - https://bit.ly/4p2svLU TikTok - https://bit.ly/4pHvnil You can purchase Dr Will Bulsiewicz’s upcoming book, ‘Plant Powered Plus: Activate the Power of Your Gut to Tame Inflammation and Reclaim Your Health’, here: https://amzn.to/45hIcb1 The Diary Of A CEO: ◼️Join DOAC circle here - https://doaccircle.com/ ◼️Buy The Diary Of A CEO book here - https://smarturl.it/DOACbook ◼️The 1% Diary is back - limited time only: https://bit.ly/3YFbJbt ◼️The Diary Of A CEO Conversation Cards (Second Edition): https://g2ul0.app.link/f31dsUttKKb ◼️Get email updates - https://bit.ly/diary-of-a-ceo-yt ◼️Follow Steven - https://g2ul0.app.link/gnGqL4IsKKb Sponsors: Stan: NO PURCHASE NECESSARY. VOID WHERE PROHIBITED. For Official Rules, visithttps://DaretoDream.stan.store Adobe Express -https://Adobe.Ly/OneBetter Fiverr:https://fiverr.com/diary and get 10% off your first order when you use code DIARY

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Episode summary

I opened with a fecal transplant that turned a life‑threatening gut infection around overnight, because it shows how central the microbiome is; more than half of what you pass is living microbes.

As a parent, are there choices that leave a lasting mark on a child’s gut?

By about age three the microbiome is essentially set, and antibiotics, bottle feeding, and cesarean birth can shift it in ways tied to more allergy, autoimmunity, and metabolic issues; the gut lining renews in just days, so daily habits really count.

Quick pause to say thank you for being here; we’re only getting started, and I’m pushing to bring you the conversations you ask for—so why are you so fired up about this new book?

Because so many modern complaints trace back to chronic, smoldering inflammation, and people need evidence‑based tools to turn it down; think of it as the immune system stuck on when there’s no threat.

Can someone look super fit and still be inflamed?

Absolutely—plenty of stage‑ready athletes message me about wrecked digestion and downstream problems despite picture‑perfect physiques.

When gut microbes weaken and the barrier frays, unwanted material slips through, the immune ‘army’ fires, and collateral damage hits your own tissues; rebuild the microbes and restore the barrier, and the immune response cools and gets precise.

Those immune alarms are cytokines that can ripple body‑wide, damaging whatever tissue is exposed, including the brain where neuroinflammation ties to mood and cognitive disease; the microbiome and immunity are inseparable.

A fecal transplant is screened donor stool delivered during colonoscopy to repopulate a failing ecosystem, and it can rescue severe C‑diff infections when antibiotics fail.

Modern living batters the gut and traps us in chronic inflammation; in cancer care, antibiotics before immunotherapy blunt success, while transplants from responders have boosted outcomes, and Parkinson’s research points to a gut‑brain story where transplants can improve movement and bowel function.

Do not DIY transplants; the durable win is rebuilding your microbiome with diet and lifestyle while safer, targeted options are studied.

Listeners keep asking about bloating and unsettled digestion—what’s usually behind it?

Constipation is the sleeper culprit and often means incomplete emptying that traps stool and microbes so gas builds; skip straws, fizzy drinks, and gum because you’ll just add air.

Gas rides with stool, and feeding microbes fiber helps them multiply and move things along, while slow transit lets them ferment anything they touch; lactose ferments easily, and many who blame gluten are reacting to fructans, which sourdough lowers, so some do better with organic or naturally low‑fructan grains.

Sourcing matters too: in the United States pre‑harvest glyphosate drying is allowed and shifts microbes toward inflammatory species, so some people tolerate organic or European wheat better.

Repair timing depends on severity; in inflammatory bowel disease the immune system rejects the microbiome, cases have surged with industrialization, antibiotics can double short‑term risk, and I’ve seen a patient with explosive C‑diff go from delirious to normal overnight with a gentle‑scope transplant as new microbiome drugs emerge.

Ignore whiplash diet extremes—organ‑only or fruit‑only both miss the mark—and remember juice cleanses can soothe symptoms briefly without rebuilding a gut; microbes adapt fast, fiber‑maxing is promising if you ramp slowly, and most people are fiber‑deficient.

Short‑chain fatty acids are the microbiome’s anti‑inflammatory payoff from fiber, and without either the microbes or the fiber you don’t make them.

Plants—fruits, vegetables, whole grains, legumes, nuts, seeds, and even mushrooms—carry fiber and polyphenols, while oils and animal foods don’t; those fatty acids fortify microbes, tighten the gut lining, and tune immune cells, which helps explain why indigenous lifestyles show lower inflammation at any age.

Alcohol tracked one‑for‑one with leaky gut and bacterial toxins in a study until blood alcohol hit zero, so I rarely drink now, and heavy use shreds the microbiome and fuels liver disease.

Curcumin, the polyphenol in turmeric, dampens specific cytokine signals, so steady, sensible use can help even though megadoses aren’t wise.

Walk us through your ‘perfect gut day’ and what breakfast should look like.

Wake at a consistent time, hydrate first with water plus a prebiotic before coffee, then get bright light and light movement to set your master clock and follow with ten calm minutes; eat earlier rather than late, go high fiber with moderate protein, skip refined sugars, and think organic oats or the occasional sourdough avocado toast.

For kids, and early‑life choices?

Model fiber‑forward breakfasts like yogurt with berries, avocado toast, overnight oats, or chia pudding; more maternal fiber in pregnancy links to fewer childhood allergies, and early antibiotics, bottle feeding, and cesarean birth shift the infant microbiome while the birth canal and breastfeeding help seed it.

You were walking us through infant microbiomes and allergy risk; what did that Finnish study actually show?

Breast milk carries diverse human milk oligosaccharides that feed a baby’s microbes, and in that cohort early antibiotics and bottle feeding were linked to later allergies, with twelve‑month microbiomes missing short‑chain‑fatty‑acid producers and low stool butyrate predicting who would struggle.

So bring that into the daily routine for gut and inflammation—what’s your morning play?

I start with a high‑fiber, moderate‑protein, low‑sugar breakfast, take evidence‑backed vitamin D, omega‑3s, and turmeric if labs say I need them, and I time them consistently to match circadian rhythms.

Morning light, movement, and a coffee set up an on‑time bowel movement, which tells me the gut is in rhythm.

You want lunch with someone, but how does that help my gut?

Feeling connected lowers the stress load that harms longevity like a daily smoking habit, and when that bond is missing the brain–gut axis fires stress hormones that inflame the gut and disturb sleep.

Have a real lunch with conversation, then get outside for a short walk to catch different daylight that lifts serotonin and focus, and even ten minutes of walking can improve glucose control and ease post‑meal bloating.

Afternoon energy and training—what timing works best?

Body temperature peaks between three and six in the afternoon, which is prime for performance, but keep hard sessions at least two hours away from bedtime.

Space meals about four hours to let the migrating motor complex sweep between them, and aim for an early dinner.

After sunset, dim indoor lights to protect melatonin, ease off devices or use blue‑light blockers, take evening zinc and magnesium if you use them, and wind down in a cool, dark room.

Does the fasting window itself matter?

Time‑restricted eating helps by giving the gut twelve hours or more of rest and by anchoring consistent meal times, and the one hard rule is to avoid late‑night eating because it hurts sleep and metabolism.

You link trauma to gut issues—what’s the pathway?

Living in sympathetic overdrive keeps the amygdala and CRH on, drives cortisol at the wrong times, and that weakens the gut barrier and fuels inflammation, while parasympathetic practices like connection, meditation, or sauna pull you back into safety.

Where do you start when trauma is part of a gut case?

You first name it as the root and then work with trained professionals, such as through cognitive behavioral therapy, rather than pushing it into a corner.

Remind me how to read the Bristol stool chart and what worries you.

Type four is the soft, formed goal, many people swing toward constipation or diarrhea, and our large UK survey found about four in ten report bowel issues.

Pellets often need fiber plus a stool‑softening magnesium like oxide, citrate, or sulfate, while magnesium glycinate is great for sleep but not for constipation, and chronic constipation can masquerade as overflow diarrhea.

What big idea from your new book did we miss?

Plant‑Powered Plus isn’t dogma; the healthiest patterns all share four pillars—fiber, polyphenols, healthy fats from whole foods, and fermented foods—and a Stanford trial showed that simply adding fermented foods for eight weeks boosted diversity and lowered inflammation.

Oils are extremely calorie dense, so if weight loss is the goal focus on whole‑food fats like nuts, seeds, avocado, or fish, and most people under‑consume all four pillars.

Your before‑and‑after is striking; what really changed?

I revamped diet and training, but the deeper shift was healing my relationship with my dad, catalyzed by my wife and the birth of my daughter, and forgiving him changed my health from the inside out.

We were estranged for a decade after a painful divorce, I achieved a lot but felt empty, and calling him helped me see how hard he had loved us.

That lesson lands; the reconnection before he passed matters, and the book release dates?

It’s out Tuesday in the US and Thursday in the UK, and you can find me as The Gut Health MD on YouTube and at theguthealthmd.com, where my free newsletter shares new studies and practical notes.

I’ll link everything and strongly recommend the book; it’s clear, current, and genuinely helpful.

I didn’t get to say goodbye, but I’d tell my dad I’m sorry it took me so long to see he was a wonderful father, and I trust I’ll get that chance.

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