About this episode
The Mitochondria Scientist Dr Martin Picard reveals why stress is secretly burning 60% of your daily energy, the science behind reversing grey hair, and why your mitochondria - not your genes - determine how fast you age! Dr Martin Picard is a Professor of Behavioral Medicine and Director of the Mitochondrial Psychobiology Group, who specialises in how stress, emotions and lived experiences affect your mitochondria. He recently published the world's first map of mitochondria in the human brain and is also the author of the upcoming book, ‘Energy’. He explains: ◼️Why depression is really an energy problem, not just in your head ◼️Why eating more food won't give you more energy, and what actually will ◼️How training for a marathon can double the mitochondria in your muscles ◼️Why people with a strong sense of purpose have more powerful mitochondria ◼️Why cancer cells abandon their mitochondria, and what it means for treating them Chapters 00:00:00 Intro 00:03:16 Why Everyone Is Suddenly Obsessed With Energy 00:04:15 Why I Dedicated My Life to Mitochondria Research 00:05:32 The Fascination With Mitochondria—and What a PhD Really Means 00:08:26 How Better Energy Can Transform Your Everyday Life 00:09:43 Where to Start If You Constantly Feel Tired 00:14:06 Why Mitochondria Are the Key to Your Health 00:16:23 How Mitochondria Made Complex Human Life Possible 00:18:44 What Insulin Resistance Reveals About Your Energy System 00:20:17 How Mitochondria Influence Cancer Risk 00:22:57 The Real Cause of the Warburg Effect 00:24:23 Why Diabetes Raises Your Risk of Cancer 00:25:50 Why Smoking Damages Cells and Causes Cancer 00:30:45 Why Hair Turns Grey—and Whether It Can Be Reversed 00:39:38 What Cortisol Is Really Doing to Your Cells 00:42:28 Does a More Resilient Mind Save Cellular Energy? 00:45:01 Acute vs. Chronic Stress: Why the Difference Matters 00:45:34 Understanding Resistance—and Why It Drains Your Energy 00:47:59 What Really Happens When You Get Your First Grey Hair 00:51:23 The Real Secret to Healthy Aging 00:53:17 How to Make Your Body More Energy Efficient 00:55:15 How Food Shapes Your Cellular Energy 01:00:42 What Mitochondria Have to Do With Alzheimer's Disease 01:05:12 Is Dementia Really "Type 3 Diabetes"? 01:11:48 Why Alzheimer's Is More Common in Western Societies 01:13:34 Ads 01:15:36 How to Eat for Maximum Energy 01:17:08 Why We Overeat Even When We're Not Hungry 01:20:26 Is Breakfast Really the Most Important Meal? 01:22:23 How to Stop Scattering Your Energy 01:30:38 How High Performers Filter Signal From Noise 01:41:45 How Energy Resistance Shows Up in Parenting 01:43:46 Why Meaningful Goals Become Magnets for Energy 01:44:27 Do People With Purpose Have Healthier Mitochondria? 01:48:15 What Being Judged Does to Your Body and Brain 01:52:59 Why Chronic Stress Leads to Visceral Fat 01:53:22 How Chronic Stress Turns Into Disease 01:54:56 What GDF-15 Is—and Can You Prevent It? 01:58:21 Can Supplements Actually Improve Mitochondrial Health? 02:02:15 How to Trust Your Body's Internal Wisdom 02:04:14 Ads 02:05:18 Can Red Light Therapy Really Boost Your Mitochondria? 02:07:05 What You Need to Know Before Trying Red Light Therapy 02:12:26 How to Listen to Your Body's Energy Signals 02:29:03 The Best Exercise Routine for Healthy Mitochondria 02:30:03 Which Blood Tests Actually Measure Mitochondrial Health? 02:32:06 The Personal Loss That Changed Everything Follow Dr Martin: Website - https://link.thediaryofaceo.com/BqY0OhF Substack - https://link.thediaryofaceo.com/4aOc0rk Metabolic Psychiatry and Ketogenic Diet - https://link.thediaryofaceo.com/GexHJoI X - https://link.thediaryofaceo.com/Fs8WGvj Instagram - https://link.thediaryofaceo.com/BsNZ7vH You can find out more about Dr Martin’s upcoming book, ‘Energy’, here: https://link.thediaryofaceo.com/5jW5yUA The Diary Of A CEO: ◼ Join DOAC circle here - https://doaccircle.com/ ◼ Buy The Diary Of A CEO book here - https://smarturl.it/DOACbook ◼ The 1% Diary is back - limited time only: https://bit.ly/3YFbJbt ◼ The Diary Of A CEO Conversation Cards: https://linkly.link/2hm7r ◼ Get email updates - https://bit.ly/diary-of-a-ceo-yt ◼ Follow Steven - https://g2ul0.app.link/gnGqL4IsKKb Sponsors: KetoneIQ - Visit https://ketone.com/STEVEN for 30% off your subscription order Cometeer - https://cometeer.com/DOAC use code DOAC for $20 off Bon Charge: https://boncharge.com/DOAC for 20% off
Episode summary
I’ve heard the best minds say sleep is the most powerful lever for performance, but today we’re digging into the engine behind it all: energy; hit follow so you don’t miss our strongest episodes, and Dr Martin Picard, what do you know that most people don’t?
We are the energy moving through our bodies, and science is finally giving us language to treat human life as an energetic process, not just a pile of parts.
People want to know what energy is, why it swings day to day, and how to help friends with long fatigue; who are you and why this field?
I’m a scientist shaped by lived highs and lows, and mitochondria became my bridge between experience and biology; watching them move for the first time made me realize life is electrons flowing toward oxygen, throwing off heat that makes us warm.
There are thousands of mitochondria in each cell and trillions in the body—who should care?
Anyone who wants to show up fully, because low, inefficient flow makes life heavy, relationships harder, and optimism scarce.
So where do we start if we want more reliable energy?
Three basics: you are the flow, your daily energy budget is finite, and growth needs resistance; stress isn’t the villain, your response is.
Show me how mitochondria fit, and weren’t they once bacteria?
They act like tiny resistors and a sensing network inside cells, and long ago an oxygen‑using microbe moved in and helped cells compute, cooperate, and build complex bodies.
You’ve said many disorders come down to energy resistance—how?
Diabetes is the clearest: too much energy pressure or sluggish mitochondria blocks smooth flow, like water piling up behind a dam, while movement opens gates and converts that flow into work.
Does this relate to cancer?
Cancer cells often sidestep mitochondria and ferment even when oxygen is available, an anti‑social throwback that then demands blood vessels to lower resistance; metabolism can drive this shift, and chronic high glucose raises pressure that damages and forces cells into protective insulin resistance.
So tumors hijack energy factories and dodge cell death?
Mitochondria normally help decide whether a cell divides, works, or dies, but cancer learns to mute that veto and use the machinery for its own growth.
Walk me from sugar overload to damage in simple terms.
Excess electrons from frequent glucose spikes jack up pressure, sedentary life limits flow, resistance rises, and stray electrons become oxidative stress that injures systems over time.
What about aging and gray hair—can stress turn it and can it reverse?
Hair holds a timeline of biology, and we found two‑tone hairs showing graying and re‑pigmentation; in cells, a cortisol‑like signal raised energy expenditure by approximately 60 percent, and in people, spikes in life stress lined up with rapid graying that sometimes reversed within weeks when stress eased.
If I get better at not overreacting, do I save energy for better work and recovery?
Yes—awareness interrupts the chain from bad news to cortisol to drain, which is why mindfulness and somatic noticing are practical energy tools.
Help me feel this resistance idea.
Exercise is clean physics: if demand outruns mitochondrial capacity, it burns; recovery then builds more mitochondria, lowers future resistance, and that’s where the benefits come from.
So gray hair is a late domino because energy gets reallocated down the body’s priority list, like presidents aging fast under strain?
Exactly—anti‑aging is wise allocation: waste less on rumination and reactivity so more can go to repair, because eating more won’t expand a fixed budget.
How do I become more efficient—training, food, alcohol?
Train to raise capacity and cut inflammation; alcohol and other toxins cost energy to clear, so you feel relaxed while your body pays the bill, and infections show the trade‑off when immune defense steals fuel from everything else.
That’s why I feel awful: some of my “soldiers” get reassigned from growth and repair.
Right, and fasting cycles help quality‑control mitochondria through mitophagy and renewal, which links to brain health more than the old plaque story.
Is that why people call Alzheimer’s type 3 diabetes?
Early on, affected regions burn extra to cope, then burn less as they tire, and chronic glucose overload raises resistance and pushes insulin resistance in brain and muscle; ketones flow with fewer steps and often feel clearer, while GLP1 drugs work by helping reduce input at the source.
Indigenous groups moving more and eating less sugar have scarce dementia, and visceral fat flags risk.
Movement keeps energy moving, overeating stores excess in risky places, and obesity reflects a deeper reality of blocked flow.
Give me eating advice for an on‑point day, and what about breakfast dogma?
Eat by feel, not habit, and most of us do better with a shorter eating window to reduce friction; the cereal‑for‑breakfast push was marketing, and many people think and perform better by not overloading early.
When I had the flu, my resting heart rate soared and my mind became diffuse; like a bulb versus a laser, the pattern of energy—not just the amount—determines range and power.
Under startup stress I lost motivation until the cash crunch eased, which taught me coherence matters; let’s talk signal versus noise.
Jobs lived 80 percent signal by executing the few must‑do items today and ignoring the rest, Musk runs almost pure signal, and even Bezos protects morning decision quality; entrepreneurs who can’t raise signal lose.
Jony Ive says focus means daily, disciplined no’s to ideas you love so all energy hits the target.
Focus isn’t a mood, it’s constant pruning; real focus is saying no to things you desperately want to do so you can finish what matters.
Give 100 percent and outcomes compound like a laser, not a lamp.
That’s resonance: a clear, felt signal in a leader entrains others, spreads coherence, and amplifies effort.
Jobs’ so‑called reality distortion field was that coherence pulling teams into what seemed impossible.
A strong source synchronizes the system, so results snowball in ways that look uncanny from the outside.
If we are energy, leadership and parenting are about shaping other energy.
Exactly—offer the right constraints and real challenges so energy transforms; without resistance there’s no growth, and with too much, you break the system.
I’ve been thinking about big goals as magnets that pull people and effort toward them, the way the moon pulled us to land there, which makes me wonder if purpose actually tunes our biology too.
In a long-running Chicago study, people who felt more purpose showed mitochondria in the prefrontal cortex that moved energy with less resistance, and animal work shows it cuts both ways—state of mind can reshape mitochondria, and mitochondria can shape how we feel.
If purpose slips and mitochondria bog down, what shows up first?
Fatigue and that burned-out, future-averse slump tend to lead, which is why many cultures try restoring purpose as part of easing depressive symptoms.
We tested mental stress in the lab and saw a blood marker of energetic friction, GDF-15, jump within minutes; it binds in the brainstem and the body acts like it’s sick—motivation drops to conserve energy while glucose and fat are mobilized, which can drive visceral fat if it becomes chronic.
And if that signal stays high, does it predict trouble, and how do we lower it?
People with higher GDF-15 are more likely to die over time and tend to avoid activity, so anything that reduces perceived threat and resets resistance helps—sleep, grounding practices like meditation, and living more in line with how we evolved.
Listeners keep asking about shortcuts: methylene blue, NAD boosters, and urolithin A—band-aids or useful tools?
I’m cautious with pills for complex problems, but here’s the gist: methylene blue can donate electrons to mitochondria; NAD carries electrons and may calm inflammation, though true deficiency is uncommon; urolithin A seems to speed cleanup of faulty mitochondria, with promising data but plenty of hype, so I still lean on body wisdom first.
Given how removed we are from nature, do we need tools to compensate, like red light therapy?
Nature exposure clearly aids recovery for reasons we’re still teasing apart, and red to near‑infrared light can reach tissue and likely nudges cytochrome c oxidase, improving electron flow; in one study, shining red light on the back during a glucose drink blunted the spike by nudging metabolism up, but dose matters.
So there’s a sweet spot, and too much light can backfire with excess oxidative stress.
Exactly—like training, there’s a hormetic curve where the right dose strengthens the system and excess overwhelms it.
We did a brief breath-hold to feel energy firsthand; as oxygen drops and carbon dioxide rises, electrons stall, which feels awful and mirrors what happens when blood flow is cut off, and even a lactate infusion can trigger panic, supporting the idea that many mental health states have an energetic component.
So the path back is purpose and the basics we covered.
Yes, plus what’s doable for the person—movement helps many, and keto has been life-changing for some with hard-to-treat mood disorders, though responses vary and averages in trials can hide who truly benefits, especially across sexes.
People with long COVID, ME/CFS, and fibromyalgia say exercise can crash them; what’s happening and how can they rebuild?
Millions live with these post‑exertional flares where stress signals spike and muscle mitochondria show reduced capacity, and while triggers differ, stories of recovery often include safety, love, and patient pacing—connection can be potent energy medicine, along with hope.
What training best builds mitochondria—zone two, intervals, or lifting?
Anything that makes you breathe harder without overshooting your capacity will do, so personalize the dose and let recovery restore the balance.
Are there practical tests for mitochondrial health?
We’re building a platform to help people sense their mitochondrial state and use that felt energy as a compass for choices in food, relationships, work, and direction.
Our closing tradition: what was the hardest thing you overcame, and how did it shape you?
We lost a pregnancy at three months and it shattered us, but sitting in the grief revealed a hard lesson—slow down—so I sharpened my focus on what truly matters and became a more present partner, father, and leader, reshaped by love, support, and the experiences that move our energy.
Thank you for your openness and for reframing life as energy in motion; it’s changed how I see myself and my work, and for anyone who wants more, where should they go?
Visit martinpicard.energy for the book, research, and core energetic principles, and thank you for this conversation.