About this episode
Dr Guy Leschziner is a consultant neurologist, sleep physician, and author who specialises in the science of sleep, circadian rhythms, and the hidden ways our brains shape our nights. In today’s moment, he unpacks how poor sleep can change everything from your appetite and weight to your emotions, cravings, and long-term health. He reveals what your body clock is really doing, and his true opinion on sleep trackers: harmful or helpful? Listen to the full episode here! Spotify: https://g2ul0.app.link/6btyk6znG2b Apple: https://g2ul0.app.link/ZFC5hNCnG2b Watch the Episodes On YouTube: https://www.youtube.com/c/%20TheDiaryOfACEO/videos Follow Guy: https://www.guyleschziner.com/
Episode summary
You said not sleeping enough raises the odds of weight gain. What’s the pathway?
Poor sleep scrambles appetite and fullness hormones, so even one short night can push calorie intake up, and years of short sleep track with greater weight gain; when we treat sleep apnea well, some people finally lose weight that used to feel stuck.
So if I’m under‑slept I eat more; am I also more likely to grab sugary junk?
Often yes, and sleep loss also worsens glucose handling and insulin sensitivity, so you crave more and process it less well.
What’s happening in the brain—amygdala, prefrontal, something in that circuit?
We don’t have a precise map, but reward systems seem to shift when we’re sleep‑deprived.
Explain circadian rhythms like I’m ten.
Every cell runs a roughly twenty‑four‑hour program coordinated by the suprachiasmatic nucleus, which sets when we feel sleepy, hungry, and sharp; genetics and daily cues like light, meals, and exercise shape its timing. Melatonin from the pineal rises in the evening, peaks near bedtime, and falls before wake, and a well‑timed tablet can nudge the clock earlier or later.
Where is that master clock?
It sits in the hypothalamus and takes light signals from special retinal cells tuned to blue light, letting the clock adjust with the seasons.
Is that the same blue light from my phone?
Sunlight is far stronger, but screens have some blue light; the light alone is usually too weak to spark insomnia, yet late‑night scrolling still delays your clock over time and the content keeps you wired, so you end up short on sleep if your wake time is fixed.
What about falling asleep to intense shows; my partner hates it and I think I need it.
Sleep is individual: a few can switch off and do fine, but for most it’s unhelpful and it erodes the bed‑equals‑sleep association that protects against insomnia.
Are most sleep problems just bad habits?
There’s broad genetic risk for insomnia and habits interact with it; sloppy routines can trigger chronic insomnia, though hygiene fixes alone rarely cure entrenched cases.
If I wanted to be terrible at sleep, what would I do?
Turn the bedroom into an office and media hub, load up on late caffeine and alcohol, skip any wind‑down, and go to bed after a heavy carb meal; alcohol may knock you out, but it fragments sleep, worsens snoring, and prompts bathroom trips.
Does sharing a bed help or hurt?
It depends on your sleep reactivity; if you’re sensitive, a snoring or restless partner can wreck your night, while others sleep better with someone beside them.
I’m tempted to ditch blinds so sunrise wakes me; good idea?
Better to keep it dark, because dawn shifts with seasons and light during sleep degrades quality and may raise diabetes risk; aim for a cool, quiet, blacked‑out room or use a sleep mask.
Are the eyes the only light sensors?
For circadian timing, yes; claims about light on the skin haven’t held up.
Still feels like odd design.
We see it in some totally blind people who lose retinal signaling and drift on a non‑twenty‑four‑hour cycle, going later each day.
I’ve seen that approximately forty percent of totally blind folks have non‑twenty‑four, and on chronotypes I think I’m an owl—though it might just be habit.
Chronotype reflects genes, age, and life—teens skew later, and many of us shift earlier with age.
Twin data say up to fifty percent genetic; does it run in families?
Often, but environment and behavior still move the needle, so genes aren’t destiny.
When someone says they haven’t slept for nights and feel awful, where do you start?
First, check whether it’s true insomnia or another disorder, because people often misjudge their sleep and lab data may show more sleep than they felt. I screen for apnea or limb movements, look for triggers, high sleep reactivity, medications, and health issues, and decide if a sleep study is needed.
Would you recommend a sleep tracker to that person?
Trackers are great for research and sometimes for awareness, but for anxious poor sleepers they often stoke worry and offer little you can act on, and their readings on awakenings and stages are shaky; better to talk to a clinician than chase numbers.
Have trackers helped or hurt sleep culture?
They likely nudged short sleepers to spend more time in bed, which helps, but for people already worried they can backfire, and alarmist messages about sleep can worsen insomnia and mental health.
For transparency, I invest in and am sponsored by a tracker, and still agree nuance matters; seeing my data helped me link poor sleep to mood, cravings, and the effect of a drink or two, but when life guarantees bad sleep I ignore the app, and parents of little kids shouldn’t bother.
We’re aligned—data helps only when you can do something with it; otherwise it just raises stress.
Nuance is key; that was one of the most replayed moments from an earlier episode, and you can find the full conversation in the description—thanks for listening.